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Two proteins found on telomeres control DNA damage response pathways

No sooner had cells evolved linear chromosomes than they had a life-threatening problem to solve. To the machinery that repairs broken DNA, chromosome ends look a lot like breaks in need of mending, so they could elicit a DNA damage response that would ultimately be lethal to cells. Telomeres, se...
Science News

Initial trigger is not enough to determine a cell's fate

Disturbing a stem cell from its initial quiescent state was once thought to taint its gold-standard properties. However, research uncovering how a signaling pathway regulates stem cell behavior reveals that stem cells, once activated, enter a window of time during which they respond to their envi...
Science News

New method better identifies functionally related genes on the bacterial chromosome

The moment a bacterial pathogen makes contact with its host, its goal is simple: to infect. To do the job, it has to turn a specific array of genes on and off and show a little know-how in adapting to its new environment. A new tool developed at Rockefeller University allows scientists to identif...
Science News

Chromosomes are responsible for a critical enzyme's activation during cell division

In a dividing cell, chromosomes interact with cellular scaffolding — called spindle microtubules — in order to move themselves to opposite ends of the cell, ensuring that both daughter cells receive an exact copy of their parent cell’s genetic material. The microtubules that form this scaffold...
Science News

MicroRNA works with Ago2 protein to regulate blood cell development

MicroRNAs became the stars of the RNA universe when, in 2001, scientists found that these short RNAs can control whether or not genes are expressed. This month, provocative new findings cast new light on the genesis of these key biological regulators and how they carry out their function. While m...
Science News

Immune cells in the brains of aging mice prove more functional than expected

As people age past 50, their brains begin to decrease in mass. But even as neurons shrink, other brain cells appear to become more active. Microglia — the small immune cells that sense injury and the presence of pathogens in the nervous system — have shown increased activity, producing higher am...

Gift from Milstein family to support melanoma research

Howard P. Milstein, a banker and philanthropist who serves as chairman of the largest privately held bank in the U.S., has, with his family, donated $5.5 million to The Rockefeller University to create the Milstein Medical Research Program. The initial research efforts will be in the area of skin...
Campus News

Announcements

The next generation In September, twenty new scientist-hopefuls will fill the gap left by this year’s graduates. Of an initial pool of 590 applicants, 12.5 percent were accepted, a number whittled down over the winter months by a screening committee overseen by the Dean’s Office and including S...
Campus News

Convocation 2007

For Rockefeller University’s newest class of scientists, the pomp and circumstance of June 21 was infused with a strong dose of high spirits. Rock­efeller’s 49th Convocation began with a Moroccan-inspired reception on June 20, followed the next day by a formal luncheon, gowning and a procession...
Campus News

Bloomberg, Wilson receive honorary degrees

by TALLEY HENNING BROWN This year’s honorary doctorate recipients are from very disparate fields. One, an entrepreneur and politician, made his name with a technology that is now ubiquitous in the financial industry. The other, a scientist and author, made his leading the vanguard in the cause of...
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