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New study reveals inner workings of a molecular clamp critical to DNA replication

From bacteria to humans, every organism must replicate its DNA. This basic process, which occurs millions of times a day in an average mammal, is driven by three core protein complexes that act as tiny machines, zipping along an unwound strand of DNA to assemble a duplicate copy. New research fro...
Awards and Honors

David Allis to receive Gairdner Award

C. David Allis, Joy and Jack Fishman Professor at Rockefeller University, is a recipient of the 2007 Gairdner Foundation International Awards. Allis is one of five scientists honored by the Gairdner Foundation for “fundamental discoveries that will have impact on human genetic development, cancer...
Science News

Building the nuclear pore piece by piece

The nuclear pore complexes are the sole gatekeepers for the cell’s nucleus — proteins, RNA, viruses, anything that passes between the nucleus and the rest of the cell has to use one of these giant protein assemblies. But exactly how each of the almost 2,000 pores that are embedded in the nuclear...
Science News

Dendritic cells may be key to reversing diabetes

When the body’s own immune system begins to assault the cells in the pancreas responsible for producing insulin, the result is type 1 diabetes. Now, researchers studying the immune system’s dendritic cells in mice have found a way to stop the destruction and help revive and maintain the populati...
Science News

Density does it: Fibrinogen concentration controls clot formation

When blood clots over a wound, the resulting scab is the product of an intricate molecular dance between cell fragments called platelets in the blood and the glycoprotein fibrinogen. Fibrinogen sticks to the wound's surface, and when platelets float by the fibrinogen it turns on a receptor on the...
Science News

To recognize their friends, mice use their amygdalas

Even those who can’t remember names can usually recall faces. New research from Rockefeller University suggests that a simple brain chemical, a neuropeptide called oxytocin, is a reason. Social recognition is an important part of normal life for animals of every species. “Remembering an individ...
Science News

Hepatitis C virus blocks 'superinfection'

There’s infection and then there’s superinfection – when a cell already infected by a virus gets a second viral infection. But some viruses don’t like to share their cells. New research from Rockefeller University shows that the hepatitis C virus, which infects cells in the liver and can cau...
Science News

Understanding ubiquitylation: Researchers identify a process that enables access to genes

It turns out there’s more than one way to skin a gene. New research from Rockefeller University suggests that two closely related DNA unpackaging mechanisms may not work the way scientists thought. Access to a gene requires a host of proteins to work in tandem to pry open DNA’s protective chrom...
Science News

New glimpse into early brain development shows how nerve cells move into position

Tucked into the lower, rear portion of the brain, the cerebellum plays key roles in motor learning, motor memory and sensory perception. It’s also where the majority of metastatic childhood brain tumors are located. Yet scientists still know very little about its early growth. Now, new research h...
Science News

Immune response to cancer stem cells may dictate cancer's course

Although stem cells hold incredible promise in the fight against certain diseases, in cancer they’re anything but helpful. In fact, mounting evidence is showing that a tumor’s growth and spread may depend on “cancer stem cells,” which comprise only a very small subset of the tumor. Now, a ne...
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