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Genes may protect against heart disease rather than be harmful as previously thought

A genetic pathway whose activity was suspected to advance heart disease by increasing inflammation in the blood vessels and arteries feeding the heart may actually protect against it at least in laboratory mice, reports a team of Rockefeller University scientists led by Jan Breslow, M.D., in the ...
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Mouse studies show brain's "master molecule" produces same behavior from three different psychostimulant drugs

Findings may lead to new drug targets for treating schizophrenia A mouse study reported in this week's Science magazine shows that three drugs, each acting on a different chemical transmitter in the brain, all produce the same schizophrenia-like symptoms by acting on a single "master molecule" in...
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By the year 2050, human population could add 2.6 billion people, reports Rockefeller scientist Joel E. Cohen

It took from the beginning of time until 1950 to put the first 2.5 billion people on the planet. Yet in the next half-century, an increase that exceeds the total population of the world in 1950 will occur. So writes Joel E. Cohen, Ph.D., Dr.P.H., professor and head of the Laboratory of Population...
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Researchers describe new technique for cataloging RNA targets in rare brain disease

CLIP-ping the messenger In journal Science, researchers describe new technique for cataloging RNA targets in rare brain disease New method may apply to diseases such as Fragile X mental retardation RNA, often thought of as merely the chemical messenger that helps decode DNA's genetic instructions...
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Giant protein organizes the transportation railway system within cells

To get its job done, each cell in the human body must constantly change its inner skeleton and therefore its outer shape. This skeleton also serves as a vast network of "tracks," which grow and shrink and move in different directions as needed to transport proteins and other materials within the ...
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GenSAT (Gene Expression Nervous System Atlas) Project announced

Unprecedented genetic access to brain provided by Rockefeller University scientists For scientists studying the brain, this week's Nature announces a remarkable new map describing previously uncharted territory, plus the means of exploring the new horizons for themselves. Rockefeller University s...
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"Gene therapy" in worms identifies protein that plays role in controlling water balance, sense of touch in live animals

Using "knockout" mice and mutant roundworms, researchers at The Rockefeller University and the University of California, San Francisco, have identified a protein that helps control water balance in the body and underlies the sensation of touch — functions basic to life that have long eluded expla...
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Improving the body's "homeland security" against TB

Immune system provides new clue to most life-threatening bacterium The microbe that causes tuberculosis operates the way a human terrorist would. With minimal resources, the TB bacterium skillfully blends in and gains strength before lashing out unexpectedly. This microbe, which claims more human...
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White House Awards National Medal of Science to Rockefeller University's James Darnell

Nation's highest scientific award honors gene regulation pioneer James E. Darnell Jr., M.D., a pioneering researcher in the field of gene regulation, will receive the National Medal of Science, the White House announced today. Darnell is among eight American scientists to receive the award, the n...
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Nobel Prize honors Rockefeller University scientist Roderick MacKinnon for revealing process of electrical signaling in humans and other living organisms

Rockefeller University Professor Roderick MacKinnon, M.D., a biophysicist and X-ray crystallographer whose exquisitely detailed portraits of a class of proteins explain the generation of nerve impulses — the electrical activity that underlies all movement, sensation and thought — is honored this...
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