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Preparing for a safe split

Rockefeller scientists show how cells establish the correct line-up of chromosomes before they divide As it prepares to divide, a human cell makes exact copies of all of its 46 chromosomes, so that the two daughter cells each can have a complete set of genetic material. The two sets must separate...
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Activation of tumor suppressor gene p53 much more complex than previously believed

It's the biochemist's twist on the old light bulb jokes: how many proteins does it take to activate a gene? Scientists in Robert Roeder's Laboratory of Molecular Biology and Biochemistry at Rockefeller University now know that, at least for gene activation by the tumor suppressor p53, the answer ...
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Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy

Research reveals impending autoimmunity can be stopped Rockefeller University researchers have for the first time demonstrated a halting of early Type 1 diabetes in mice by restoring a critical class of T cells to their normal balance. The findings, reported in the June 7 issue of theJournal of ...
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Cell growth and death controlled by a single pathway in lymphoma cancer model

Researchers provide first molecular description of a cancer caused by bacteria New research at Rockefeller University, published this week in the online edition of the Proceedings of the National Academy of Sciences, helps explain why some people do not respond to chemotherapy and offers a possib...
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Molecular image of genotoxin reveal how bacteria damage human DNA

The three-dimensional structure of a DNA-damaging, bacterial toxin has been visualized by scientists at Rockefeller University. The molecular image of the toxin, published in the May 27 issue of the journalNature, shows exactly how the toxin is put together at the molecular level and damages huma...
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Newly discovered gene controls levels of "bad" cholesterol in mice

Heart disease researchers at Rockefeller University have discovered the function of a gene associated with high cholesterol levels in humans. Using mice as test subjects, the Rockefeller scientists determined that the gene, called Pcsk9, can decrease the number of receptors on liver cells that re...
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Brain visualized in real time as animal "smells"

In real time in a living animal, scientists have observed regions of the brain as they respond to odors. The Rockefeller University study with mice, reported as the cover story in the April 8 issue of the journal Neuron, promises to advance research on how animals, as well as humans, sense odors....
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Fat hormone leptin alters brain architecture and activity, which in turn shapes feeding behavior

Plasticity plays a dramatic role Scientists at the Howard Hughes Medical Institute and The Rockefeller University in collaboration with investigators at Yale University have found that leptin — a hormone found in fat tissue and critical to regulating weight - affects both the architecture and fun...
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Mouse produced from cloning a single neuron yields answers about the genetics of olfaction

The "Sleeper" project Like your nose, your immune system is primarily a detection device. Its chief job is to detect and identify molecules. Just as there is an almost infinite number of smells, there's a nearly infinite number of microbial invaders that must be properly distinguished from one an...
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Rockefeller University scientists take on controversial and widely publicized "vibration theory" of smell

Two researchers at Rockefeller University have put a controversial theory of smell to the sniff test and have found no evidence to support it. They say their study, published in the April issue of Nature Neuroscience, should raise firm doubts about the validity of "vibration theory," which states...
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