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Wrong Proteins Targeted in Battle Against Cancer?

Lasker recipient James E. Darnell contends drug developers should focus more on "transcription factor" proteins Researchers may be looking for novel cancer drugs in the wrong places, says Rockefeller University Professor James E. Darnell Jr., M.D., in an article in this month's Nature Reviews Ca...

"CAF" protein mystery solved by AIDS researchers

Blood proteins shown to thwart HIV provide clues to potential new treatment Acclaimed AIDS researcher David Ho, M.D., a Rockefeller University Irene Diamond Professor who heads the Aaron Diamond AIDS Research Center (ADARC), and his research team, have discovered that several natural proteins -a...

Lasker Award Honors Rockefeller University's James Darnell

"Special Achievement in Medical Science" recognizes a groundbreaking researcher, influential writer and mentor James E. Darnell Jr., M.D., the pioneering researcher in the field of gene regulation — who has nurtured the careers of over 100 young, talented scientists — was honored today with the...

One gene, two important proteins

Researchers discover gene variation in cancer-causing "STAT" family encodes two —not one—functional proteins When the Human Genome Project first revealed last year that humans possess only an estimated 30,000 genes — fives times more than a mustard weed plant — the fact that many of our g...

Rockefeller researchers provide the first functional evidence for mammalian pheromone receptors

Pheromones — chemical signals that influence social and reproductive behaviors — have been studied since the 1950s, but the molecules in the mammalian nervous system that actually detect pheromones have remained elusive. Now, a team of researchers, led by The Rockefeller University's Peter Momb...

Dinosaur ancestor's vision possibly nocturnal

Researchers recreate 240-million year old protein in test tube Call it "Triassic Park": with statistics, instead of amber-preserved DNA, researchers at the Howard Hughes Medical Institute at The Rockefeller University and Yale University recreated in the test tube a functional pigment that would ...

Natural-born killers enlisted to fight anthrax

Phage enzymes may offer powerful novel method to wipe out anthrax bacteria in seconds Researchers at The Rockefeller University have hit upon a promising method for rapidly and effectively treating people infected with the deadly anthrax bacterium — including feared drug-resistant strains. The ...

Pivotal Brain Processor Decreased in Schizophrenia

Lower Levels Could Explain Disruption in Mental Function; Study Points Toward Better Treatments New York, NY (August 14, 2002) -- Levels of a pivotal signal processor in the brain are reduced significantly in people with schizophrenia, a study by scientists at The Rockefeller University, Weill Co...

What inspires yeast cells to divide?

Rockefeller scientists discover unexpected trigger Often in science a novel set of experiments comes along that forces researchers to abandon old models in exchange for new ones that better fit their observations. This is the case in a new Nature report by Rockefeller University researchers, wh...

Researchers discover molecular "switch" that tells body to store or burn fat

Findings add important new information about how leptin regulates body weight and metabolism An enzyme called SCD-1 plays a crucial role —through the hormone leptin —in signaling the body to either store fat or burn it, report a team of scientists in the July 12 issue of the journal Science. T...