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West Nile infections are spiking. Here’s why the percentage of severe cases is so small
...By studying WNV outbreaks in multiple countries going back 20 years, Rockefeller’s Jean-Laurent Casanova and his collaborators discovered that about 40% of cases of neuroinvasive WNV can be linked to the presence of immune system proteins called autoantibodies that sabotag...
An immune flaw may cause West Nile virus’s deadliest symptoms
...What is it that makes these select few so vulnerable? An international team of researchers led by Rockefeller University’s Jean-Laurent Casanova and Alessandro Borghesi of the San Matteo Research Hospital in Pavia, Italy, recently pinpointed the cause: an autoimmune defect...
New findings on TB could change how we treat inflammatory disorders    
...The current study, led by Rockefeller’s Stéphanie Boisson-Dupuis and Jean-Laurent Casanova, revealed a genetic cause of TNF deficiency, as well as the underlying mechanism: a lack of TNF incapacitates a specific immune process in the lungs, leading to severe—but surprising...
Jean-Laurent Casanova appointed HHMI investigator
Jean-Laurent Casanova, senior attending physician at The Rockefeller University Hospital and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has been named one of 27 new investigators with the Howard Hughes Medical Institute (HHMI), the nonprofit me...
Newly discovered genetic malfunction causes rare lung disease
...The researchers, including Rockefeller’s Jean-Laurent Casanova and Institut Imagine’s Anna-Lena Neehus, recently published their results in Cell. The study also found that the children are missing half of their alveolar macrophages, which are located in the air sacs of the...
Jean-Laurent Casanova honored with the Korsmeyer Award
Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, is the recipient of the 2016 Stanley J. Korsmeyer Award for his work investigating the genetic basis of pediatric infectious diseases. The award, given by the Ameri...
Homing in on the genetics of severe COVID in children
...The patients are sick not because of the virus,” says Rockefeller geneticist Jean-Laurent Casanova. “They're sick because they excessively respond to the virus.” Inborn errors An enduring mystery of COVID has been its wildly varied impact on individuals, with one person ge...
Jean-Laurent Casanova to receive 2014 Robert Koch Award
Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has been awarded the 2014 Robert Koch Award from the Berlin, Germany based Robert Koch Foundation. Casanova shares the prize with Alain Fischer from the Collège de France ...
Eight Rockefeller scientists designated most influential researchers
...The 2022 list includes: Paul Bieniasz Marina Caskey Luciano Marraffini Jean-Laurent Casanova James G. Krueger Michel C. Nussenzweig Jeffrey V. Ravetch Charles M. Rice Clarivate selects influential scientists for its prestigious list by first compiling the most highly cited...
Jean-Laurent Casanova receives the 2016 Inserm Grand Prix
Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has won the 2016 Inserm Grand Prix for his work on the genetic basis of infectious diseases. The prestigious award, given annually by Inserm—the French National Ins...
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