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Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has been named the Seymour and Vivian Milstein Award for Excellence in Interferon and Cytokine Research 2012 laureate. He will receive the prize at the annual meeting of the International Society of ...

A research collaboration involving Rockefeller University and more than two dozen other institutions has found a link between a gene mutation and chronic kidney failure. The study, published in Nature Genetics in July, found patients who had a specific kind of kidney disease — called karyomegalic...

Growing Pains: Nations Balance Growth, Power Needs   "These days electricity is so important to industrial society that providing adequate power isn't good enough. For example, businesses that rely on the Internet simply can't afford to be without power, even for a minute. Sure, it was a nuisance...

The Journal of Experimental Medicine online: August 7, 2012 Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood Melina Herman, Michael Ciancanelli, Yi-Hung Ou, Lazaro Lorenzo, Maja Klaudel-Dreszler, Elodie Pauwels, Vanessa Sancho-Shimizu, Rebeca ...

Technology: Problem or Solution?   "On the other hand, ask [Jesse Ausubel] about climate change (a subject he helped make the hot topic it is today), or overpopulation, or deforestation and you’ll get a surprisingly reassuring answer: things are getting better, we’re on the right track. It’s...

Cell 150: 533-548 (August 3, 2012) Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling Moumita Chaki, Rannar Airik, Amiya K. Ghosh, Rachel H. Giles, Rui Chen, Gisela G. Slaats, Hui Wang, Toby W. Hurd, Weibin Zhou, Andrew Cluckey, Heon Yun...

Science online: August 2, 2012 Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency Dusan Bogunovic, Minji Byun, Larissa A. Durfee, Avinash Abhyankar, Ozden Sanal, Davood Mansouri, Sandra Salem, Irena Radovanovic, Audrey V. Grant, Parisa Adimi, Nahal Mansour...

The Journal of Clinical Investigation online: August 1, 2012 Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections Amandine Crequer, Anja Troeger, Etienne Patin, Cindy S. Ma, Capucine Picard, Vincent Pedergnana, Claire Fieschi, Annick Lim, Avinash Abhyankar, Laure Gi...

Molecular Cell online: July 26, 2012 DNA methylation dynamics during in vivo differentiation of blood and skin stem cells Christoph Bock, Isabel Beerman, Wen-Hui Lien, Zachary D. Smith, Hongcang Gu, Patrick Boyle, Andreas Gnirke, Elaine Fuchs, Derrick J. Rossi and Alexander Meissner

Cancer cells are immortal because they circumvent failsafe mechanisms that stop out-of-control cell proliferation. One of these mechanisms – the progressive shortening of chromosomes – is prevented by replenishment of telomeres, the protective elements at the ends of chromosomes. Most cancer cel...