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In brief: Variation between strains may account for differences in people’s vulnerability to infection

New research shows that subtle differences between bacterial strains may cause dramatic differences in outcome between people infected with the same microbe.

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In brief: How the immune system curbs its own mistakes

Researchers discovered how apoptosis keeps potential cancer-causing mutations in check.

Proof of principle: Tri-I TDI drug candidates “graduate” to next phase of development

As inaugural Sanders Director Dr. Michael Foley is set to depart the Tri-Institutional Therapeutics Discovery Institute later this year, two projects from a portfolio of 57 that the Tri-I TDI has supported are now ready for the next phase of therapeutic development—a phase intended to lead to inv...

3D imaging of fat reveals potential targets for new obesity treatments

With new imaging methods, scientists hope to make significant progress in the fight against obesity. A new report reveals striking images of neural projections within fat tissue, and clues for the development of new drugs.

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In brief: Immune cells surveil intestine to prevent infections

Scientists found that immune cells called intraepithelial lymphocytes act as a surveillance force at the intestine, helping to generate an appropriate immune response to both friendly bacteria and dangerous pathogens.

In brief: New clues about how cells restart stalled replication

Scientists studying the cell’s DNA-copying machinery have discovered a molecular mechanism that helps reactivate it should it stop prematurely. Its function may prevent genetic errors like those that cause cancer.

Brain research points the way to new treatments for nicotine addiction

Scientists have discovered a group of brain cells that may play a role in keeping smokers addicted to nicotine. Their work could ultimately lead to new drugs to help people conquer their tobacco dependence.

Neuroscientist Vanessa Ruta promoted to associate professor

Ruta, who explores how brains produce such flexible responses to fixed stimuli, has been promoted to Gabrielle H. Reem and Herbert J. Kayden associate professor.

Daniel Kronauer, who uses ants to study social behavior, is promoted

Kronauer has been promoted to associate professor. He has dedicated his laboratory to investigating the molecular basis underlying complex social behavior among insects.

Mosquito sex protein could provide key to controlling disease

A protein transferred from male to female mosquitoes during sex influences female mating behavior—a phenomenon that could be exploited to limit the spread of mosquito-borne illnesses like Zika and dengue.